There is little difference between THC and CBD molecules in terms of structure. When you consume either cannabinoids orally, the human GI system destroys most of it before absorption. There is a sublingual gland beneath the tongue. When you consume CBD oil, it is absorbed into your bloodstream via this vein. Vaporized CBD enters the lungs directly and allows for a higher absorption rate.
Here is a quick overview of general absorption rates depending on consumption method:
The likely absorption rate is between 10% and 20%. A few studies have found a bioavailability rate of just 6%, however. CBD goes through your digestive system before it reaches the bloodstream. The process can take up to two hours. During this timeframe, much of the CBD is filtered out by the liver and digestive tract. Examples of orally consumed CBD products include gummies, capsules, and edibles like chocolate.
When you use CBD topically, the cannabinoid engages with the endocannabinoid receptors in the peripheral nervous system. It is arguably the best method if you aim to treat a specific area on the body. The cannabinoid interacts with local receptors in your skin, so it doesn’t enter the bloodstream. As such, topically applied CBD is not a good option for more severe conditions. This is because these conditions require the cannabinoid to bind to CB receptors in the central nervous system and brain.
Researchers have yet to quantify the bioavailability of topical CBD products accurately. Some studies found that CBD suppositories have an absorption rate of approximately 13.5%. Products include creams and salves.
The probable absorption rate of sublingually consumed CBD is between 13% and 19%. Some research suggests it is as high as 35%, though most experts disagree. Holding CBD beneath the tongue ensures the sublingual gland absorbs it. It then enters the bloodstream and gets to work.
Most users claim to feel effects within 20 seconds. Make sure you keep the oil beneath the tongue for 30-60 seconds. Conventional sublingual products include CBD sprays, oils, and tinctures.
The process of inhaling CBD is the most effective on the list in absorption terms. Vaporization offers a bioavailability of between 34% and 46%. Some studies claim the rate is even higher at 56%. When you vape CBD, it enters the bloodstream directly. It binds to endocannabinoid receptors in the body very quickly. You may experience effects within minutes. You can use a vape pen in this instance.
CBD liposomes could take bioavailability to the next level, however.